For the most part, no nail polish will cause you no serious harm. It can cause minor Problems like your headache, but overall, it's a safe product. You're probably just having a reaction to the solvents. Nail polish solvents are chemicals (like acetones, ketones, and xylenes) that dissolve and then evaporate. They allow the plasticizers chemicals that add flexibility to the polish and the film-formers chemicals that add hardness and Abrasion resistance to the nail and gloss to the polish to solidify. These ingredients release into the air before the polish dries and are probably the cause of your headaches.
An easy fix is to do your nails in a well-ventilated room, either near an open window or next to a fan. That should help, but if it doesn't, try different brands and different colors -- you may find that the formulas of some are simply less volatile than others. You may also want to lean toward ketone-based polishes (rather than acetone- and xylene-based ones) for the same reason, so check the labels. Solvent-induced headaches are just one of several
Health problems associated with nail polish use. Another is contact dermatitis, an allergic reaction by the skin to one of the components in nail polish. Symptoms include redness, itching, flaking, or cracking, and in the worst cases, mild blisters around the cuticles. Contact dermatitis from nail polish also can cause reactions to other parts of the body, including the face, neck, or genital area  if you should happen to touch them before your nails are completely dry. If you have such a reaction, stop using that particular polish and try a different brand or color. Toluene-sulfonamide resin appears to be the ingredient responsible for almost all allergies, so some manufacturers have started producing hypoallergenic nail polishes that contain a substitute for it. If, however, you can't find a nail polish that doesn't aggravate your allergy and your symptoms persist, you should see a dermatologist. He or she can help you identify the particular chemicals or dyes that are causing your reactions so you will know which ones to avoid. One other fairly insignificant problem associated with nail polish stems from certain deep red colors. Polishes that contain the dyes D&C Red Numbers 6, 7, and 34, as well as Number 5 Lake, can leave a
Temporary yellow stain on your nails, especially if you use them often or wear them for longer than a week at a time. In general, though, unless every polish you try makes you uncomfortable or prompts allergic reactions, there's usually no reason to avoid painting your nails (although you should consult your physician before considering its use during Pregnancy).